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Jaime Costales, PhD.Jaime Costales

 

 

 

 

 


Trypanosoma cruzi host/parasite interactions and epidemiology of Chagas disease in Ecuador

  Estudios  Education: 

 

  • 2008. Postdoctoral fellow Immunology and Infectious Diseases. Harvard University.
  • 2004. PhD. in Molecular and Cellular Biology. Ohio University, OH, USA.
  • 1999. Bachelor in Biology. Pontificia Universidad Católica del Ecuador. 

 

Cargo actual  Current position: 

 

  • Principal Investigator at the Center for Research on Health in Latin America. (Immunology, Parasitology, Molecular Biology).
  • Professor at the School of Biological Sciences. College of Exact and Natural Sciences. Pontificia Universidad Católica del Ecuador.

 

Investigación actual  Current research (PUCE): Health and Vulnerable Groups. 

  

Publicaciones recientes  Recent publications

 

  • Vela, A., Coral-Almeida, M., Sereno, D., Costales, J.A., Barnabé C, Brenière SF (2021) In vitro susceptibility of Trypanosoma cruzi discrete typing units (DTUs) to benznidazole: A systematic review and meta-analysis. PLoS Negl Trop Dis 15(3): e0009269. https://doi.org/10.1371/journal.pntd.0009269
  • Talavera-López, C., Messenger, L.A., Lewis, M.D., Yeo, M., Reis-Cunha, J.L., Matos, G.M., Bartholomeu, D.C., Calzada, J.E., Saldaña, A,, Ramírez, J.D., Guhl, F., Ocaña-Mayorga, S., Costales, J.A., Gorchakov, R., Jones, K., Nolan, M.S, Teixeira, S.M.R., Carrasco, H.J., Bottazzi, M.E., Hotez, P.J., Murray, K.O., Grijalva, M.J., Burleigh, B., Grisard, E.C., Miles, M.A. and Andersson, B. (2021). Repeat-Driven Generation of Antigenic Diversity in a Major Human Pathogen, Trypanosoma cruzi. Front. Cell. Infect. Microbiol. 11(77):614665. doi: 10.3389/fcimb.2021.614665
  • Maiguashca Sánchez, J., Sueto, S. O. B., Schwabl, P., Grijalva, M. J., Llewellyn, M. S., & Costales, J. A. (2020). Remarkable genetic diversity of Trypanosoma cruzi and Trypanosoma rangeli in two localities of southern Ecuador identified via deep sequencing of mini-exon gene amplicons. Parasites & Vectors, 13(1), 252. doi:10.1186/s13071-020-04079-1
  • Schwabl, P., Maiguashca Sánchez, J., Costales, J. A., Ocaña-Mayorga, S., Segovia, M., Carrasco, H. J., . . . Llewellyn, M. S. (2020). Culture-free genome-wide locus sequence typing (GLST) provides new perspectives on Trypanosoma cruzi dispersal and infection complexity. PLOS Genetics, 16(12), e1009170. doi:10.1371/journal.pgen.1009170
  • Bates, B. R., Moncayo, A. L., Costales, J. A., Herrera-Cespedes, C. A., & Grijalva, M. J. (2020). Knowledge, Attitudes, and Practices Towards COVID-19 Among Ecuadorians During the Outbreak: An Online Cross-Sectional Survey. Journal of community health, 10.1007/s10900-020-00916-7. Advance online publication. https://doi.org/10.1007/s10900-020-00916-7

 

Libros

  • Costales, J. A. (2017). 26 - Cell invasion by Trypanosoma cruzi and the type I interferon response. In J. Telleria & M. Tibayrenc (Eds.), American Trypanosomiasis Chagas Disease (Second Edition) (pp. 605-627). London: Elsevier. https://doi.org/10.1016/B978-0-12-801029-7.00027-7

 

 Redes  ReseachGate https://www.researchgate.net/profile/Jaime_Costales