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The aim of this research was to assess prostate cancer mortality rates in Latin American and Caribbean (LAC) countries and to predict their mortality up to 2030. Data were obtained from the World Health Organization Mortality Database, and age-standardized mortality rates (ASMRs) for prostate cancer per 100,000 men between 1997 and 2017 were estimated for most LAC countries. Annual percentage change was calculated by country and age group. Nordpred was used to project prostate cancer mortality to 2030. Between 1997 and 2017, the countries with the highest prostate cancer mortality rates were Trinidad & Tobago, Cuba and Venezuela. For all ages, ten Latin American and Caribbean countries recorded significant decreases of between -0.5% and -2.8%, while Brazil, Cuba, Guatemala and Venezuela registered increases. Global prostate cancer mortality will increase by 2030 due to changes in population structure and size.

Prostate cancer is a public health problem. It is the second most common cancer and the fifth leading cause of cancer death in men worldwide. In 2020, the World Cancer Observatory (Globocan) reported approximately 1 415 000 new cases (14.1% of the total) of prostate cancer and 375 000 deaths (6.8% of the total), representing an incidence rate of 30.7 per 100 000 and a mortality rate of 7.7 per 100 000. Although the incidence of prostate cancer is increasing worldwide, mortality rates vary greatly from region to region. Prostate cancer remains the leading malignancy in men in Latin America and the Caribbean (LAC), which has some of the highest mortality rates in the world. In recent decades, several LAC countries continue to report high prostate cancer mortality rates. For example, in 2015, Cuba reported the highest mortality rates (23.2 per 100 000), followed by Venezuela (20/100 000) and Chile (15/100 000),while Peru reported mortality rates ranging from 20.9 in 2005-2009 to 24.1 in 2010-2014 per 100 000.

Despite the decline in prostate cancer mortality rates over the past two decades in most countries of the region, some countries still have very high mortality rates. By 2030, most countries in the region will see an overall increase in the number of deaths, mainly due to population size.

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