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Jaime Costales, PhD.

contacto 02JACOSTALESC@puce.edu.ec    

Research groups: Infectious and tropical diseases

OneHealth

Research areas: Epidemiology / Parasitology / Infectious, immunological and chronic diseases / OneHealth. 

  

 Investigacin actual  Current research:  

  • Trypanosoma cruzi host/parasite interactions and epidemiology of Chagas disease in Ecuador.

 

Estudios  Education: 

 

  • 2008. Postdoctoral fellow Immunology and Infectious Diseases. Harvard University.
  • 2004. PhD. in Molecular and Cellular Biology. Ohio University, OH, USA.
  • 1999. Bachelor in Biology. Pontificia Universidad Católica del Ecuador. 

 

Cargo actual  Current position: 

 

  • CISeAL Director. 2023 - present.
  • Principal Investigator at the Center for Research on Health in Latin America. (Immunology, Parasitology, Molecular Biology).
  • Professor at the School of Biological Sciences. College of Exact and Natural Sciences. Pontificia Universidad Católica del Ecuador.

 

  

Publicaciones recientes  Recent publications: 

  • Telleria, J. & Costales, J.A. (2025). An Overview of Trypanosoma cruzi Biology Through the Lens of Proteomics: A Review. Pathogens, 14(4):337. https://doi.org/10.3390/pathogens14040337
  • López-Rosero, A., Sippy, R., Stewart-Ibarra, A. M., Ryan, S. J., Mordecai, E., Heras, F., Beltrán, E., Costales, J. A., & Neira, M. (2024). High prevalence of Zika virus infection in populations of Aedes aegypti from South-western Ecuador. PLOS Neglected Tropical Diseases, 17(9), e0011908. https://doi.org/10.1371/journal.pntd.0011908
  • Proaño-Bolaños, C., Morán-Marcillo, G., Espinosa de Los Monteros-Silva, N., et al. (2024). Bioactivity of synthetic peptides from Ecuadorian frog skin secretions against Leishmania mexicana, Plasmodium falciparum, and Trypanosoma cruzi. Microbiology Spectrum, 12(8):e0333923. https://doi.org/10.1128/spectrum.03339-23
  • Mora-Criollo, P., et al. (2023). High growth hormone serum partially protects mice against Trypanosoma cruzi infection. FEBS Open Bio, 13(7), 1346–1356. https://doi.org/10.1002/2211-5463.13627
  • Telleria, J., et al. (2023). Comparative proteomic analysis of Trypanosoma cruzi TcI lineage epimastigotes unveils metabolic and phenotypic differences between fast- and slow-dividing strains. Experimental Parasitology, 252:108576. https://doi.org/10.1016/j.exppara.2023.108576
  • Bates, B.R., Villegas-Botero, A., Costales, J.A., Moncayo, A.L., Tami, A., Carvajal, A., Grijalva, M.J. (2022). COVID-19 Vaccine Hesitancy in Three Latin American Countries: Reasons Given for Not Becoming Vaccinated in Colombia, Ecuador, and Venezuela. Health Communication, 37(12), 1465–1475. https://doi.org/10.1080/10410236.2022.2035943
  • Hernandez-Castro, L.E., Villacís, A.G., Jacobs, A., Cheaib, B., Day, C.C., Ocaña-Mayorga, S., et al. (2022). Population genomics and geographic dispersal in Chagas disease vectors: Landscape drivers and evidence of possible adaptation to the domestic setting. PLOS Genetics, 18(2):e1010019. https://doi.org/10.1371/journal.pgen.1010019
  • Mora-Criollo, P., et al. (2022). Growth hormone modulates Trypanosoma cruzi infection in vitro. Growth Hormone & IGF Research, 64:101460. https://doi.org/10.1016/j.ghir.2022.101460
  • Talavera-López, C., Messenger, L.A., Lewis, M.D., Yeo, M., Reis-Cunha, J.L., Matos, G.M., et al. (2021). Repeat-Driven Generation of Antigenic Diversity in a Major Human Pathogen, Trypanosoma cruzi. Frontiers in Cellular and Infection Microbiology, 11:614665. https://doi.org/10.3389/fcimb.2021.614665
  • Ferreira, E.R., Bonfim-Melo, A., Burleigh, B.A., Costales, J.A., Tyler, K.M., Mortara, R.A. (2021). Parasite-Mediated Remodeling of the Host Microfilament Cytoskeleton Enables Rapid Egress of Trypanosoma cruzi following Membrane Rupture. mBio, 12(3):e0098821. https://doi.org/10.1128/mBio.00988-21
  • Vela, A., Coral-Almeida, M., Sereno, D., Costales, J.A., Barnabé, C., Brenière, S.F. (2021). In vitro susceptibility of Trypanosoma cruzi discrete typing units (DTUs) to benznidazole: A systematic review and meta-analysis. PLOS Neglected Tropical Diseases, 15(3):e0009269. https://doi.org/10.1371/journal.pntd.0009269
  • Mora-Criollo, P., Basu, R., Qian, Y., Costales, J.A., Guevara-Aguirre, J., Grijalva, M.J., Kopchick, J.J. (2021). The Effect of the GH/IGF-1 Axis During Trypanosoma cruzi Infection. Journal of the Endocrine Society, 5(Suppl_1):A492–A493. https://doi.org/10.1210/jendso/bvab048.1007
  • Calvopiña, M., Segovia, G., Cevallos, W., Vicuña, Y., Costales, J.A., Guevara, A. (2020). Fatal Acute Chagas Disease by Trypanosoma cruzi DTU TcI, Ecuador. BMC Infectious Diseases, 20(1):143. https://doi.org/10.1186/s12879-020-4851-0
  • Maiguashca Sánchez, J., Sueto, S.O.B., Schwabl, P., Grijalva, M.J., Llewellyn, M.S., Costales, J.A. (2020). Remarkable genetic diversity of Trypanosoma cruzi and Trypanosoma rangeli in two localities of southern Ecuador identified via deep sequencing of mini-exon gene amplicons. Parasites & Vectors, 13(1):252. https://doi.org/10.1186/s13071-020-04079-1
  • Bates, B.R., Moncayo, A.L., Costales, J.A., Herrera-Cespedes, C.A., Grijalva, M.J. (2020). Knowledge, attitudes, and practices towards COVID-19 among Ecuadorians during the outbreak: An online cross-sectional survey. Journal of Community Health, 45(6), 1158–1167. https://doi.org/10.1007/s10900-020-00916-7
  • Schwabl, P., Maiguashca Sánchez, J., Costales, J.A., Ocaña-Mayorga, S., Segovia, M., Carrasco, H.J., Hernández, C., Ramírez, J.D., Lewis, M.D., Grijalva, M.J., Llewellyn, M.S. (2020). Culture-free genome-wide locus sequence typing (GLST) provides new perspectives on Trypanosoma cruzi dispersal and infection complexity. PLOS Genetics, 16(12):e1009170. https://doi.org/10.1371/journal.pgen.1009170

 

Libros

  • Costales, J. A. (2017). 26 - Cell invasion by Trypanosoma cruzi and the type I interferon response. In J. Telleria & M. Tibayrenc (Eds.), American Trypanosomiasis Chagas Disease (Second Edition) (pp. 605-627). London: Elsevier. https://doi.org/10.1016/B978-0-12-801029-7.00027-7

 

 Redes  ReseachGate:  https://www.researchgate.net/profile/Jaime_Costales